Catalase-mediated cyclization: Synthesis of 3-allyl-4-imino substituted 2(1H)-quinazolinones and 1,3-benzoxazine-2(3H)-ones
✍ Scribed by Ahmed Kamal; P.B. Sattur
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 134 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
The cyclization of N-ally1 carbamoyl anthranilonitriles as well as O-allylcarbamoyl salicylonitrile to Z(lH)-quinazolinones and 1,3-benzoxazine-2(3H)-ones in quantitative yields by employing catalase has been described.
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Two new and efficient synthetic routes towards substituted 4H-1,4-benzoxazine derivatives were reported. The first one involves the synthesis in four steps of the 4-Boc-4H-1,4-benzoxazine and its regioselective substitution on C-3 following a lithiation-electrophilic substitution sequence. The secon
## Abstract A novel one‐pot approach for the synthesis of aryl substituted quinazolin‐4(3__H__)‐ones and 2,3‐dihydro‐4(1__H__)‐quinazolinones has been reported based on the reductive desulfurization of 3‐aryl‐2‐thioxo‐4(3__H__)‐quinazolinones with nickel boride in dry methanol at ambient temperatur