𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Catabolism of Alzheimer's amyloid-β: Implications for brain clearance and plaque deposition

✍ Scribed by McIntee, Farron L.; Blais, Steven; Neubert, Thomas; Mathews, Paul; Rostagno, Agueda; Ghiso, Jorge


Book ID
122527876
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
46 KB
Volume
6
Category
Article
ISSN
1552-5260

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Diphenylpropynone derivatives as probes
✍ Masahiro Ono; Hiroyuki Watanabe; Rumi Watanabe; Mamoru Haratake; Morio Nakayama; 📂 Article 📅 2011 🏛 Elsevier Science 🌐 English ⚖ 428 KB

A new series of diphenylpropynone (DPP) derivatives for use in vivo to image β-amyloid (Aβ) plaques in the brain of patients with Alzheimer's disease (AD) were synthesized and characterized. Binding experiments in vitro revealed high affinity for Aβ (1-42) aggregates at a K(i) value ranging from 6 t

Peripheral reduction of β-amyloid is suf
✍ J. Gregor Sutcliffe; Peter B. Hedlund; Elizabeth A. Thomas; Floyd E. Bloom; Bria 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 276 KB

Three loci that modify β-amyloid (Aβ) accumulation and deposition in the brains of a mouse model of Alzheimer's disease have been previously described. One encompasses the Psen2 gene encoding presenilin 2, a component of the γ-secretase activity responsible for generating Aβ by proteolysis. We show