𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Castor oil: new lessons from an ancient oil

✍ Scribed by T. S. Gaginella; F. Capasso; N. Mascolo; S. Perilli

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
71 KB
Volume
12
Category
Article
ISSN
0951-418X

No coin nor oath required. For personal study only.

✦ Synopsis

Castor oil, from Ricinus communis, has been used since ancient times as a safe and reliable laxative. The pharmacologically active molecule in the oil is ricinoleic acid. This hydroxylated, long-chain fatty acid has multiple effects on the intestinal mucosa, resulting in fluid secretion. Early studies indicated that the mucosal effects were due to enteritis or interference with cellular metabolism. Later studies revealed that the fatty acid could increase mucosal permeability and cause cytotoxicity, associated with release of eicosanoids, platelet activating factor, other autacoids and nitric oxide. In addition, ricinoleic acid disrupts normal intestinal motility. The combination of these effects on the mucosa and smooth muscle of the gut account for its laxative action.

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