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Case report: Psychosis associated with hepatitis B

✍ Scribed by Dr. H. C. Weber; J. F. Schoeman; A. Nowitz; M. L. B. Becker

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
376 KB
Volume
44
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

An acute disintegrative disorder in a child with acute hepatitis B virus (HBV) infection is described. Both hepatitis B surface antigen (HBsAg) and HBV‐DNA were detected in cere‐brospinal fluid (CSF) by means of enzyme‐linked immunosorbent assay (ELISA) and the poly‐merase chain reaction (PCR) technique respectively. A markedly elevated level of CSF adeny‐late kinase (AK), which normalised as the patient recovered spontaneously, suggested an organic brain disorder. Demonstration of intra‐blood‐brain barrier production of IgG supported the possibility of local infection by HBV within the central nervous system. © 1994 Wiley‐Liss, inc.

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