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Cascade of fever production in mice infected with influenza virus

✍ Scribed by Kurokawa, Masahiko; Imakita, Masami; Kumeda, Cristina A.; Shiraki, Kimiyasu

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
666 KB
Volume
50
Category
Article
ISSN
0146-6615

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✦ Synopsis

The cascade of fever production in influenza was studied. To analyse fever production in a murine model, we selected DBN2 mice that have the highest susceptibility in fibrile responses among seven mouse strains. lntranasal influenza infection-and interferon (IFN)-induced fever production was studied in this mouse model. Fever was induced prominently on day 2 after influenza infection and IFN activity was also increased in serum. Only the level of interleukin (lL)-la, an endogenous pyrogen, rose markedly in serum among cytokines (IL-la, IL-2, IFN-y, and tumor necrosis factor-a) examined. Fever was induced 14 hr after intraperitoneal IFN-a treatment and IL-la level rose significantly in the serum of the IFN-a-treated mice as compared with that of untreated mice. Fever production was significantly suppressed by treatment with anti-IFN-cw/P or anti-IL-la antibody in infected mice and the former signficantly suppressed responsive IL-la production, indicating that elevated IFN activity induced IL-la production and subsequentlyfever production in infected mice. The activity of cyclooxygenase (COX) that produces prostaglandin (PG)E, was significantly augmented in the brain of infected mice on day 2 after infection. Fever production was suppressed by the inhibition of COX activity with aspirin, although IL-la level was maintained at the elevated level. Therefore, influenza infection in mice turned on the following cascade for fever induction: IFN production, IL-la production, elevated COX activity, and PGE2 production. We elucidated the relationship among IFN activity, IL-la production and COX activity and demonstrated the cascade of fever production in influenza infection.

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