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Carrier detection of the X-linked primary immunodeficiency diseases using X-chromosome inactivation analysis

✍ Scribed by Winkelstein, Jerry A.; Fearon, Eric


Book ID
119059780
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
1010 KB
Volume
85
Category
Article
ISSN
1097-6825

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The pattern of X-chromosome inactivation was analyzed, by means of two different DNA probes (pSPT-PGK and M27 beta), in several cell lineages derived from females belonging to a pedigree with X-linked immunodeficiency with hyper-IgM (HIGM1). Non-random X-chromosome inactivation was demonstrated in T