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Caretaker Brca1: keeping the genome in the straight and narrow

โœ Scribed by Veronica Yu


Book ID
120700851
Publisher
BioMed Central
Year
2000
Tongue
English
Weight
115 KB
Volume
2
Category
Article
ISSN
1465-5411

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## Communicated by Richard Wooster Mutations in the BRCA1 and BRCA2 genes predispose women to breast and ovarian cancer. BRCA1 and BRCA2 are 83 and 86 kb long, with coding sequences of 5.7 and 10.2 kb, scattered over 22 and 26 coding exons, respectively. The large majority of the alterations ident