✦ LIBER ✦

Cardiovascular effects of methamphetamine in Parkinson's disease patients

✍ Scribed by Nicola Pavese; Ornella Rimoldi; Alexander Gerhard; David J. Brooks; Paola Piccini

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 621 KB
Volume: 19
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.10651

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Cardiovascular responses after intravenous methamphetamine were assessed in 11 Parkinson's disease (PD) patients. Systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), and electrocardiogram (ECG) were monitored for 103 minutes. After methamphetamine administration, SBP and DBP increased significantly in both PD and normal controls whereas placebo had no effect. In PD patients, however, the duration of SBP and DBP responses to methamphetamine and the maximum increase from baseline was attenuated compared with the controls. A significant correlation was found between individual BP responsiveness and the Unified Parkinson's Disease Rating Scale (UPDRS) motor score. These findings suggest that in PD there is impairment of catecholamine release from peripheral sympathetic presynaptic terminals, which correlates with motor impairment. © 2003 Movement Disorder Society

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