Cardiovascular actions and therapeutic potential of tanshinone IIA
โ Scribed by Si Gao; Zhiping Liu; Hong Li; Peter J. Little; Peiqing Liu; Suowen Xu
- Book ID
- 118423675
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 278 KB
- Volume
- 220
- Category
- Article
- ISSN
- 0021-9150
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Tanshinone IIA is a derivative of phenanthrene-quinone isolated from Danshen, a widely used Chinese herbal medicine. It has antioxidant properties and cytotoxic activity against multiple human cancer cell lines, inducing apoptosis and differentiation of some human cancer cell lines. Our purpose was
A series of 2,2'-(substituted methylene)bis-(1,6,6-trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione) derivatives were synthesized by the reaction of tanshinone IIA (D(1)) and aromatic aldehyde in the presence of p-TsOH. Bromination derivative of D(1) and hydrolysis product of cryptotan