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Cardiac effects of halofantrine in children suffering from acute uncomplicated falciparum malaria

โœ Scribed by A Sowunmi; C.O. Falade; A.M.J. Oduola; O.A.T. Ogundahunsi; F.A. Fehintola; G.O. Gbotosho; P. Larcier; L.A. Salako

Book ID
108369114
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
418 KB
Volume
92
Category
Article
ISSN
0035-9203

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The cardiac effects ofhalofantrine (HF) and chloroquine plus chlorpheniramine (CQ-CP), a histamine Hi antagonist which reverses chloroquine insensitivity in Plasmodium falciparum in vitro and in vivo, were assessed in 41 children with acute svmntomatic uncomnlicated P fa&arum malaria bv electrocardi

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In the face of growing chloroquine resistance of Plasmodium falciparum, efforts to prolong the clinical usefulness of the drug have partly concentrated on its combination with potential resistance-reversing compounds. However, clinical studies on such combinations have been limited. We have compared