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Cardiac arrhythmogenic action of benzo(a)pyrene in the rabbit

✍ Scribed by Carlson, Gary P.; White, James F.

Book ID
124121572
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
449 KB
Volume
15
Category
Article
ISSN
0378-4274

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## Abstract The potent carcinogen benzo[a]pyrene (B[a]P) and its metabolite B[a]P __trans__‐7, 8‐dihydrodiol (7, 8‐diol) require metabolic activation by the microsomal cytochrome P450s (P450s) to exert several adverse biological effects, including binding to DNA, toxicity, mutagenicity, and carcino