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CARD4/Nod1 mediates NF-κB and JNK activation by invasive Shigella flexneri

✍ Scribed by Girardin, Stephen E; Tournebize, Régis; Mavris, Maria; Page, Anne-Laure; Li, Xiaoxia; Stark, George R; Bertin, John; DiStefano, Peter S; Yaniv, Moshe; Sansonetti, Philippe J; Philpott, Dana J


Book ID
119770159
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
670 KB
Volume
2
Category
Article
ISSN
1469-221X

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Induction of proliferation in primary resting T cells requires engagement of both the antigenspecific TCR and the co-stimulatory receptor CD28. Here we report that CD28 functions as an autonomous mitogenic receptor which is mobilized by TCR signaling through cytoskeletal rearrangement. Shortcutting