Carcinoma of lung in four siblings

✍ Scribed by Ronald Brisman; R. Robinson Baker; Ronald Elkins; William H. Hartmann

• Publisher: John Wiley and Sons
• Year: 1967
• Tongue: English
• Weight: 657 KB
• Volume: 20
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(196711)20:11<2048::aid-cncr2820201134>3.0.co;2-a

✦ Synopsis

A Negro family is presented in which all four of eight siblings older than 50 have developed carcinoma of the lung. Attention is drawn to the possible genetic and environmental factors which are etiologically related to cancer of the human lung. Several favorable factors in the prognosis of these four siblings are discussed. VIDENCE FOR THE ROLE OF GENETIC FACTORS E in cancer of the human lung is limited. This case report describes a Negro family in which four of eight sibIings developed carcinoma of the lung. The parents are not consanguineous and there is no positive family history of any type of neoplasm prior to 1964. The four siblings developed carcinoma of the lung during their fifth decade and are the only siblings older than 50. All of the siblings smoke but only one has had a strong exposure to another known carcinogen, chromium. A search of the English literature reveals no other single family with such a high incidence of pulmonary carcinoma. CASE REPORTS Case 1. I . . J., a 59-year-old man, had * Advanced Clinical Fellow, American Cancer Society. t Clinical Fellow, American Cancer Society. Addreqs for reprints: Neurological Institute, 710 West 168th Street, New York, N.Y. Grateful acknowledgement is extended to W. Bradley King, Jr., M.D. for providing the specimens for histologic examination of the operative specimen of P. J. and to Dr. Digamber S. Borgaonkar for chromosomal studies.