Hypermethylation of cytosines in CpG-rich islands of the promoter regions of regulatory genes has been discovered as a common mechanism of gene silencing during carcinogenesis. We analysed 64 primary lung carcinomas for promoter methylation of the tumour suppressor genes (TSGs) p16 (p16(INK4a)/CDKN2
Lung carcinoma in former smokers
β Scribed by Longzheng Tong; Margaret R. Spitz; John J. Fueger; Christopher I. Amos
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 588 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
β¦ Synopsis
BACKGROUND.
A reduction in the risk of lung carcinonia and a lower death rate among former smokers (FS) compared with current smokers (CS) have been documented in numlerous U.S. and international studies. The main objective of our study was to compare the differences in demographic and clinical characteristics in groups stratified by smoking status and gender to evaluate the effect of smoking history and cessation on age at lung carcinoma diagnosis and on specific histologic type.
METHODS.
We conducted a cross-sectional study of lung cancer at The University of Texas M. D. Anderson Cancer Center from January 1986 to December 1990 and from January 1992 to December 1993. This study included 1039 patients age 19-88 with confirmed primary lung carcinoma who responded to self-administered risk factor questionnaires. Among them, 497 patients (47.83%) were CS, 444 patients (42.73%) were FS, 98 patients (9.43%) had never smoked (NS), and 840 patients (80.8%) were heavy ;smokers (more than 20 pack-years).
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