✦ LIBER ✦

Carcinogenicity of trichloroethylene: fact or artifact?

✍ Scribed by D. Henschler; E. Eder; T. Neudecker; M. Metzler

Publisher: Springer-Verlag
Year: 1977
Tongue: English
Weight: 187 KB
Volume: 37
Category: Article
ISSN: 0340-5761
DOI: 10.1007/bf00355492

No coin nor oath required. For personal study only.

✦ Synopsis

Technical trichloroethylene has been found carcinogenic in mice after high daily doses per os. A GC-MS analysis of this technical sample revealed the presence of considerable amounts of epichlorohydrin and 1.2-epoxibutane as stabilizers. These epoxides are highly mutagenic in the Ames test and are, most probably, responsible for the carcinogenic effect found in mice. The question whether trichloroethylene is carcinogenic or not remains open.

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