✦ LIBER ✦

Carcinogenicity of nitrosamines and methanesulphonate esters given intraperitoneally, in RF mice

✍ Scribed by N. K. Clapp

Book ID: 102276196
Publisher: John Wiley and Sons
Year: 1973
Tongue: French
Weight: 383 KB
Volume: 12
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910120320

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Single injections of dimethylnitrosamine (DMN), diethylnitrosamine (DEN), methyl methanesulfonate (MMS), and ethyl methanesulphonate (EMS) were given intraperitoneally to male RF mice at various doses. DEN induced lung adenomas, liver hepatomas and forestomach tumors (squamous‐cell carcinomas and papillomas) at all doses, and Leydig‐cell tumors of the testis at the highest dose given. DMN, while increasing lung tumor incidence, failed to induce liver tumors when given intraperitoneally —in contrast to high incidences obtained by oral administration. The reason for this difference is not obvious at this time. MMS and EMS were not carcinogenic as used in this study. None of these alkylating agents was leukemogenic.

📜 SIMILAR VOLUMES

A study of nitrosamines and S-carboxyl d

A study of nitrosamines and S-carboxyl derivatives of cysteine as lung carcinogens in adult SWR mice

✍ S. S. Mirvish; Louise Kaufman 📂 Article 📅 1970 🏛 John Wiley and Sons 🌐 French ⚖ 362 KB

## Abstract Four nitrosamines were tested as lung carcinogens in SWR mice, and the results were compared with those obtained for urethan. In general, two doses were injected intraperitoneally into adult mice. Dimethylnitrosamine (DMN) and diethylnitrosamine (DEN) were about as highly active as uret

Chemical induction of thymomas in AKR mi

Chemical induction of thymomas in AKR mice: Interaction of chemical carcinogens and endogenous murine leukemia viruses. Comparison of N-methyl-N-nitrosourea and methyl methanesulphonate

✍ William Warren; Jeremy P. Clark; Emily Gardner; Gilmour Harris; Colin S. Cooper; 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 858 KB

## Abstract The time course of development of thymic lymphoma, which occurs spontaneously in mice of the AKR strain, is accelerated by the methylating agents __N__‐methyl‐__N__‐nitrosourea (MNU) and methyl methanesulphonate (MMS). Since MNU is a potent mutagen inducing G → A transition mutations an

Effect of Germ-free Status and Antilymph

Effect of Germ-free Status and Antilymphocyte Serum on Induction of Various Tumours in Mice by a Chemical Carcinogen given at Birth

✍ GRANT, G. A.; ROE, F. J. C. 📂 Article 📅 1969 🏛 Nature Publishing Group 🌐 English ⚖ 110 KB

No evidence of toxicity or carcinogenici

No evidence of toxicity or carcinogenicity of pentaerythritol tetranitrate given in the diet to F344 rats and B6C3F1 mice for up to two years

✍ John R. Bucher; James Huff; Joseph K. Haseman; Scot L. Eustis; Herman S. Lilja; 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 515 KB

Toxicology and carcinogenesis studies of pentaerythritol tetranitrate (PETN), an organic nitrate used in explosives and as a therapeutic agent for angina pectoris, were conducted by administering diets containing PETN,NF (National Formulary Grade, a 1:4 mixture of PETN and lactose) to both sexes of