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Carcinogenicity of heterocyclic amines for the pancreatic duct epithelium in hamsters

✍ Scribed by Masatoshi Yoshimoto; Masahiro Tsutsumi; Katsumichi Iki; Yasutaka Sasaki; Toshifumi Tsujiuchi; Takashi Sugimura; Keiji Wakabayashi; Yoichi Konishi


Book ID
117469496
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
102 KB
Volume
143
Category
Article
ISSN
0304-3835

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## Abstract Alteration of the __Fhit__ gene was investigated in pancreatic duct adenocarcinomas induced by __N__‐nitrosobis(2‐oxopropyl)amine (BOP) in Syrian golden hamsters. The animals received 70 mg/kg BOP, followed by repeated exposure to an augmentation pressure regimen consisting of a choline