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Carcinogenesis by nitrosobis-(2-oxopropyl)amine labeled with deuterium and by nitroso-2-hydroxypropyl-2-oxopropylamine in rats and hamsters

✍ Scribed by Lijinsky, W.; Saavedra, J.E.; Kovatch, R.M.

Book ID: 123341458
Publisher: Elsevier Science
Year: 1988
Tongue: English
Weight: 462 KB
Volume: 42
Category: Article
ISSN: 0304-3835
DOI: 10.1016/0304-3835(88)90236-4

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## Abstract Alteration of the __Fhit__ gene was investigated in pancreatic duct adenocarcinomas induced by __N__‐nitrosobis(2‐oxopropyl)amine (BOP) in Syrian golden hamsters. The animals received 70 mg/kg BOP, followed by repeated exposure to an augmentation pressure regimen consisting of a choline