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Inhibitory effect of esculin on oxidative DNA damage and carcinogenesis induced by N-nitrosobis(2-oxopropyl)amine in hamster pancreas

✍ Scribed by Takao Kaneko; Shoichi Tahara; Fumiyo Takabayashi; Noboru Harada


Book ID
112010617
Publisher
IOS Press
Year
2004
Tongue
English
Weight
28 KB
Volume
22
Category
Article
ISSN
0951-6433

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## Abstract Alterations of the __Rassf1a__ gene were investigated in pancreatic duct adenocarcinomas (PDAs) induced by N‐nitrosobis(2‐oxopropyl)amine (BOP) in hamsters. Female Syrian golden hamsters received 70 mg/kg BOP, followed by repeated exposures to an augmentation pressure regimen consisting