Inhibitory effect of esculin on oxidative DNA damage and carcinogenesis induced by N-nitrosobis(2-oxopropyl)amine in hamster pancreas
β Scribed by Takao Kaneko; Shoichi Tahara; Fumiyo Takabayashi; Noboru Harada
- Book ID
- 112010617
- Publisher
- IOS Press
- Year
- 2004
- Tongue
- English
- Weight
- 28 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0951-6433
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The effect of selenium intake on the development of pancreatic cancer was investigated in female Syrian golden hamsters. Four-week-old hamsters were divided into 2 groups Mcording to the selenium level in their drinking water and were fed a purified diet containing less than 0.05 ppm selenium. Start
## Abstract Alterations of the __Rassf1a__ gene were investigated in pancreatic duct adenocarcinomas (PDAs) induced by Nβnitrosobis(2βoxopropyl)amine (BOP) in hamsters. Female Syrian golden hamsters received 70 mg/kg BOP, followed by repeated exposures to an augmentation pressure regimen consisting