Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics
β Scribed by Imai, K.; Yamamoto, H.
- Book ID
- 115468738
- Publisher
- Oxford University Press
- Year
- 2007
- Tongue
- English
- Weight
- 434 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0143-3334
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## Abstract Gastric cancer is a common aggressive malignancy. Although its incidence shows considerable variation among different countries, gastric cancer is still a major health problem worldwide. The causes of stomach cancer are not completely understood. What is clear is that gastric cancer is
Microsatellite instability (MSI)-mutator phenotype variably targets microsatellite-like sequences in coding regions of cancer-related genes. Intratumor histological heterogeneity of gastric carcinoma with MSI was evaluated and found to be linked with the topographical distribution of MSI-associated