Carboxyl esterase activity of carcinoembryonic antigen?
β Scribed by Thomas, P; Westwood, J H
- Book ID
- 109833417
- Publisher
- Nature Publishing Group
- Year
- 1975
- Tongue
- English
- Weight
- 267 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0007-0920
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## Abstract Binding of globulins to ^125^I CEA was detected in 10 of 24 sera from patients with cancer, 13 of 26 sera from blood donors, and 7 of 27 supernates of tumorβcell suspensions. Binding was predominantly by IgM in 10 of 14 sera tested by radioimmunoelectrophoresis. Binding was inhibited by
## Abstract In order to determine the structure of the tumorβspecific immunodominant group of the carcinoembryonic antigen (CEA) of human gastroβintestinal tumors, immunologically active fragments from this glycoprotein were prepared by partial enzymatic hydrolysis using the proteolytic enzyme naga