Carboxamides Combining Favorable Olfactory Properties with Insect Repellency

✍ Scribed by Jean-Marc Gaudin; Thierry Lander; Olga Nikolaenko

• Book ID: 102776042
• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 689 KB
• Volume: 5
• Category: Article
• ISSN: 1612-1872
• DOI: 10.1002/cbdv.200890058

✦ Synopsis

Abstract

By a simple methodology, we have synthesized 68 carboxamides, with structural analogy to the most efficient mosquitoes repellent DEET (N,N‐diethyl‐m‐toluamide, 9). Eight of them have very promising olfactory profiles. In addition, 34 carboxamides have been tested for their repellency properties against three breeds of cockroach; six of them are excellent in this domain. Two of these, the 2‐ethyl‐N‐isopropyl‐N‐methylbutanamide and N,N‐diallyl‐2‐ethylbutanamide combine both the positive aspects, and are thus very good candidates for use in functional perfumery, and more particularly in home‐care formulations.