Antidermatophytic properties of griseofulvin derivatives with potential systemic insect-repellent activity
✍ Scribed by Robert G. Crounse
- Publisher
- John Wiley and Sons
- Year
- 1969
- Tongue
- English
- Weight
- 291 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0022-3549
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✦ Synopsis
The antidermatophytic properties of a number of grisan and coumaranone derivatives, designed as potential systemic insect repellents, have been evaluated in vitro. Comparisons of their antimycotic efficacy with the corresponding in vitro activity of established antidermatophytic agents (e.g., griseofulvin and aliphatic carboxylic acids) have been made. Several derivatives were active antifungal agents, though of lesser potency than griseofulvin itself. Differing species specificity suggests differences in antimycotic properties and might allow individual molecular design and selection for enhanced inhibition of a given dermatophytic species.