## Background: Diffuse pontine gliomas remain one of the most lethal of pediatric malignancies despite the use of increasingly intensive therapies. we delivered intensive chemotherapy during and following 70.2 gy of hyperfractionated radiation therapy in an attempt to improve survival. ## Procedur
Carboplatin for the Treatment of Children with Newly Diagnosed Optic Chiasm Gliomas: A Phase II Study
β Scribed by Victor M. Aquino; Daniel W. Fort; Barton A. Kamen
- Book ID
- 110232568
- Publisher
- Springer US
- Year
- 1999
- Tongue
- English
- Weight
- 30 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0167-594X
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## Abstract ## BACKGROUND Ninety percent of children with diffuse, intrinsic brainstem tumors will die within 18 months of diagnosis. Radiotherapy is of transient benefit to these children, and a potential way to improve its efficacy is to add radiosensitizers. Carboplatin is antineoplastic and ra
## BACKGROUND. Prognosis for the majority of children with brain stem gliomas is dismal. In previous studies, recombinant beta-interferon (@IF) has been shown to be effective for children with recurrent brain stem gliomas and may also act synergistically with radiotherapy (RT). ## METHODS. Thir