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Carbonic Anhydrase Inhibitors: Synthesis and Topical Intraocular Pressure Lowering Effects of Fluorine-Containing Inhibitors Devoid of Enhanced Reactivity

✍ Scribed by de Leval, Xavier; Ilies, Monica; Casini, Angela; Dogné, Jean-Michel; Scozzafava, Andrea; Masini, Emanuela; Mincione, Francesco; Starnotti, Michele; Supuran, Claudiu T.

Book ID: 120458716
Publisher: American Chemical Society
Year: 2004
Tongue: English
Weight: 139 KB
Volume: 47
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm031116j

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In order to find novel active compounds, complexes such as (I)-(III) are prepared. Whereas the parent sulfonamide shows no topical pressure-lowering effects in rabbits in a 2% solution the compounds (I) and (II) are more active than dorzolamide and thus are basis for a new generation of antiglaucoma