The first example of intermolecular carbon radical addition to unactivated aldoxime ethers in the preseace of BF3.OEt2 has provided a new efficient carbon-carbon bond-forming method for the synthesis of a variety of amines.
Carboncarbon bond formation by addition of σ-radicals to alkenes
✍ Scribed by Bernd Giese; González Gómez Juan Antonio
- Book ID
- 104220951
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- French
- Weight
- 102 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
Hypophosphorous acid (H3PO2) and its corresponding l-ethylpiperidine salt have been used to mediate carbon-carbon bond forming radical reactions in both aqueous and organic media.The methods used avoid many of the problems associated with tributyltin hydride based methodoh)gy.
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Terminal alkenes of the type H 2 C C(OR 1 )X, in which R 1 is a tertiary alkyl or a 1-cyclopropylethyl group and X=Ph, OSiMe 2 Bu t , OEt or H, undergo radical-chain reactions with organic halides R 2 Hal to give carbonyl compounds R 2 CH 2 C( O)X.