Carbon Nanotubes for Biomedical Applications

✍ Scribed by Vittoria Raffa, Orazio Vittorio, Cristina Riggio, Gianni Ciofani, Alfred Cuschieri (auth.), Rüdiger Klingeler, Robert B. Sim (eds.)

• Publisher: Springer-Verlag Berlin Heidelberg
• Year: 2011
• Tongue: English
• Leaves: 285
• Series: Carbon Nanostructures
• Edition: 1
• Category: Library

✦ Synopsis

This book explores the potential of multi-functional carbon nanotubes for biomedical applications. It combines contributions from chemistry, physics, biology, engineering, and medicine. The complete overview of the state-of-the-art addresses different synthesis and biofunctionalisation routes and shows the structural and magnetic properties of nanotubes relevant to biomedical applications. Particular emphasis is put on the interaction of carbon nanotubes with biological environments, i.e. toxicity, biocompatibility, cellular uptake, intracellular distribution, interaction with the immune system and environmental impact. The insertion of NMR-active substances allows diagnostic usage as markers and sensors, e.g. for imaging and contactless local temperature sensing. The potential of nanotubes for therapeutic applications is highlighted by studies on chemotherapeutic drug filling and release, targeting and magnetic hyperthermia studies for anti-cancer treatment at the cellular level.

✦ Table of Contents

Front Matter....Pages i-xix
Front Matter....Pages 1-1
Physical Properties of Carbon Nanotubes for Therapeutic Applications....Pages 3-26
Carbon Nanotubes in Regenerative Medicine....Pages 27-39
Filling of Carbon Nanotubes with Compounds in Solution or Melted Phase....Pages 41-65
Filling of Carbon Nanotubes: Containers for Magnetic Probes and Drug Delivery....Pages 67-82
Front Matter....Pages 83-83
Magnetic Nanoparticles for Diagnosis and Medical Therapy....Pages 85-95
Feasibility of Magnetically Functionalised Carbon Nanotubes for Biological Applications: From Fundamental Properties of Individual Nanomagnets to Nanoscaled Heaters and Temperature Sensors....Pages 97-124
Nuclear Magnetic Resonance Spectroscopy and Imaging of Carbon Nanotubes....Pages 125-150
Front Matter....Pages 151-151
Exploring Carbon Nanotubes and Their Interaction with Cells Using Atomic Force Microscopy....Pages 1-16
Uptake, Intracellular Localization and Biodistribution of Carbon Nanotubes....Pages 169-182
Recognition of Carbon Nanotubes by the Human Innate Immune System....Pages 183-210
Toxicity and Environmental Impact of Carbon Nanotubes....Pages 211-219
Front Matter....Pages 221-221
Carbon Nanotubes Loaded with Anticancer Drugs: A Platform for Multimodal Cancer Treatment....Pages 223-245
Carbon Nanotubes Filled with Carboplatin: Towards Carbon Nanotube-Supported Delivery of Chemotherapeutic Agents....Pages 247-258
Functionalized Carbon Nanotubes for Gene Biodelivery....Pages 259-273
Back Matter....Pages 275-278

✦ Subjects

Biomedical Engineering;Biophysics and Biological Physics;Biomaterials;Biochemical Engineering;Cell Biology