Carbon Monoxide-Free One-Step Synthesis of Isoindole-1,3-diones by Cycloaminocarbonylation of o-Haloarenes Using Formamides

✍ Scribed by Dinesh N. Sawant; Yogesh S. Wagh; Kushal D. Bhatte; Bhalchandra M. Bhanage

• Book ID: 102829083
• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 514 KB
• Volume: 2011
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/ejoc.201101000

✦ Synopsis

Abstract

A new carbon monoxide‐free, solvent‐free, single step protocol for the synthesis of isoindole‐1,3‐diones from o‐haloarenes using palladium acetate and xantphos catalysis is reported. The wider applicability of this protocol for several types of o‐iodoarenes and a few o‐bromoarenes makes it attractive. Aryl iodides and aryl bromides provided moderate to excellent yields of up to 93 %.