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Carbon-13 NMR characterization of the bispyridinium oximes, toxogonin, HS-3, HS-6 and HI-6

✍ Scribed by D. Waysbort; D. Balderman; G. Amitai

Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
405 KB
Volume
16
Category
Article
ISSN
0749-1581

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✦ Synopsis

Abstract

The structure of the bispyridinium oximes, toxogonin, HS‐3, HS‐6 and HI‐6, used as antidotes in organophosphorus poisoning, is confirmed by ^13^C NMR spectroscopy. The ^13^C NMR spectra of the corresponding monopyridinium precursors substantiate the signal assignment in the bispyridinium oxime spectra. In all oximes studied the hydroxyiminomethyl group (CHNOH) exists in the syn configuration. The ^13^C signal differences also readily allow analysis of binary mixtures of the oximes and provide an easy method for monitoring their stability.

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