Carbanion addition to acetylenes : An efficient stereoselective route to α-methylene-γ-lactams
✍ Scribed by Ranjan Patra; Swaraj B. Maiti; Amareshwar Chatterjee; Ajit K. Chakravarty
- Book ID
- 108381487
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- French
- Weight
- 215 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
The presence of an a-methylene-y-butyrolactone is essential for cytotoxic activity3 among the sesquiterpene lactones. Recently it has been established 3c,4 that the presence of a lipophilic, conjugated ester side chain located homoallylic to the exocyclic double bond of an a-methylene-ybutyrolactone
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γ-Oxo-α,β-unsaturated δ-lactones and lactams, which are in high yields, of the corresponding α-amino-γ-oxo-α,βunsaturated δ-lactones and -lactams, compounds of great easily accessible from their corresponding 2-furylcarbinols, were used as substrates for the 1,4-reductive addition of biological and