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Carbamoyl Radical-Mediated Synthesis and Semipinacol Rearrangement of β-Lactam Diols

✍ Scribed by Betou, Marie; Male, Louise; Steed, Jonathan W.; Grainger, Richard S.

Book ID
121831104
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
991 KB
Volume
20
Category
Article
ISSN
0947-6539

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✍ Matthew A. Williams; Marvin J. Miller 📂 Article 📅 1990 🏛 Elsevier Science 🌐 French ⚖ 161 KB

The c~-diazoester I in the presence of catalytic Rh2(OAc)4 was converted to the carbapenam 2. The synthesis of 1 and a proposed mechanism are described. A variety of strategies currently exists in the literature for the synthesis of bicyclic 13-1actams.