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CAR-modified anti-CD19 T cells for the treatment of B-cell malignancies: rules of the road

✍ Scribed by Gill, Saar; Porter, David L


Book ID
121390402
Publisher
Informa plc
Year
2013
Tongue
English
Weight
465 KB
Volume
14
Category
Article
ISSN
5847-4714

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For the treatment of minimal residual disease in patients with leukemias and malignant lymphomas, we constructed a heterodimeric diabody specific for human CD19 on B cells and CD3β‘€ chain of the T cell receptor complex. The bispecific diabody was expressed in Escherichia coli using a vector containin