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Development and application of CD19-specific T cells for adoptive immunotherapy of B cell malignancies

✍ Scribed by Laurence J.N. Cooper; Zaid Al-Kadhimi; David DiGiusto; Michael Kalos; David Colcher; Andrew Raubitschek; Steve J. Forman; Michael C. Jensen


Book ID
116303945
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
639 KB
Volume
33
Category
Article
ISSN
1079-9796

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For the treatment of minimal residual disease in patients with leukemias and malignant lymphomas, we constructed a heterodimeric diabody specific for human CD19 on B cells and CD3β‘€ chain of the T cell receptor complex. The bispecific diabody was expressed in Escherichia coli using a vector containin