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CAR-mediated repression of Foxo1 transcriptional activity regulates the cell cycle inhibitor p21 in mouse livers

✍ Scribed by Kazantseva, Yuliya A.; Yarushkin, Andrei A.; Pustylnyak, Vladimir O.


Book ID
121738107
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
340 KB
Volume
321
Category
Article
ISSN
0300-483X

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## Abstract Transforming growth factor‐β (TGF‐β) inhibits epithelial cell growth, in part via transcriptional induction of the cell cycle inhibitor p21^WAF1/Cip1^ (p21). We show that bone morphogenetic protein (BMP)‐7 induces higher p21 expression than TGF‐β1 in various epithelial cells. Despite th