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Capturing the Structure of a Catalytic RNA Intermediate: The Hammerhead Ribozyme

✍ Scribed by Scott, W. G.; Murray, J. B.; Arnold, J. R. P.; Stoddard, B. L.; Klug, A.


Book ID
121157202
Publisher
American Association for the Advancement of Science
Year
1996
Tongue
English
Weight
1000 KB
Volume
274
Category
Article
ISSN
0036-8075

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Elucidation of the catalytic mechanism and structure-function relationship studies of the hammerhead ribozyme continue to be an area of intensive research. A combination of diverse approaches, such as X ray crystallography, spectral studies, chemical modifications, sequence variations and kinetic an