𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Capillary Electrophoresis of RNA Oligonucleotides: Catalytic Activity of a Hammerhead Ribozyme

✍ Scribed by Jan Saevels; Ann Van Schepdael; Jos Hoogmartens

Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
117 KB
Volume
266
Category
Article
ISSN
0003-2697

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Activity and Stability of Hammerhead Rib
Activity and Stability of Hammerhead Ribozymes Containing 2β€²-C-Methyluridine: a New RNA Mimic
✍ Mariana Gallo; Rosel Kretschmer-Kazemiβ€…Far; Georg Sczakiel; Adolfoβ€…M. Iribarren πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 72 KB

We propose 2'-C-methylnucleotides as a new class of 2'-modified RNA mimics. These analogues are expected to provide 2'-OH groups capable of reproducing the interactions observed in natural RNA and, due to the presence of the Me group, to possess increased stability towards nucleases. In this work, w

Attenuation of telomerase activity by ha
Attenuation of telomerase activity by hammerhead ribozyme targeting human telomerase RNA induces growth retardation and apoptosis in human breast tumor cells
✍ Marie Yeo; Sung Young Rha; Hei Cheul Jeung; Shen Xiong Hu; Sang Hwa Yang; Yang S πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 French βš– 322 KB

## Abstract Ribozyme possesses specific endoribonuclease activity and catalyzes the hydrolysis of specific phosphodiester bonds, which results in the cleavage of target RNA sequences. Here, we evaluated the ability of hammerhead ribozymes targeting human telomerase RNA (hTR) to inhibit the catalyti