Kinetic assessment of luminal degradatio
Kinetic assessment of luminal degradation of orally effective prodrugs for rational drug development
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Takashi Mizuma
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Article
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2010
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John Wiley and Sons
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English
β 297 KB
Although prodrugging (prodrug derivatization) is a powerful technique for improving the pharmacokinetic characteristics of drugs, the intestinal pharmacokinetics of prodrugs has yet to be elucidated fully. A previous article reported the kinetic requirement of prodrugs to overcome membrane barriers.