Capillary Electrophoretic Profile of β2-Microglobulin Intermediate Associated With Hemodialysis
✍ Scribed by Yoshihiro Motomiya; Yoshinori Uji; Yukio Ando
- Book ID
- 114842808
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 397 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1091-6660
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## Abstract β2‐Microglobulin (β2m) is the light chain of the class‐I major histocompatibility complex, being also the causing agent of dialysis‐related amyloidosis, which results from its accumulation as amyloid material in the skeletal joints. This study describes conformational properties of β2m
Alternative conformations of h 2 -microglobulin (h 2 m) are involved in its transformation from soluble monomeric precursor molecules to the insoluble polymeric material that constitutes h 2 m amyloid. Accordingly, non-native conditions such as low pH or high ionic strength promote h 2 m amyloid for