Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in β-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-κB involvement
✍ Scribed by Giuseppe Esposito; Daniele De Filippis; Maria Chiara Maiuri; Daniela De Stefano; Rosa Carnuccio; Teresa Iuvone
- Book ID
- 116768497
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 169 KB
- Volume
- 399
- Category
- Article
- ISSN
- 0304-3940
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## Abstract Expression of inducible nitric oxide synthase (iNOS), which leads to the production of nitric oxide (NO), is stimulated by proinflammatory cytokines such as interleukin‐1β (IL‐1β) and tumor necrosis factor‐α (TNF‐α). Here we report on the roles of nuclear factor‐κB (NF‐κB) and mitogen‐a
## Abstract Cytokine‐induced expression of inducible nitric oxide synthase (iNOS) and concomitant production of nitric oxide (NO) involve activation of mitogen‐activated protein (MAP) kinases and are in most cases mediated by the transcription factor NF‐κB. We investigated the role of p38 MAP kinas