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Canine lymphoma-associated antigens defined by murine monoclonal antibodies

โœ Scribed by Zenon Steplewski; K. Ann Jeglum; Carlos Rosales; Nancy Weintraub

Publisher
Springer-Verlag
Year
1987
Tongue
English
Weight
536 KB
Volume
24
Category
Article
ISSN
0340-7004

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โœฆ Synopsis

Lymphoma in dogs resembles human non-Hodgkin's lymphoma in pathological presentation, immunophenotype, and response to therapy, thus representing a good model for comparative studies with human disease. Monoclonal antibodies (MAbs) were derived from mice immunized with a dog lymphoma cell line. Three MAbs were selected for further application in immunophenotyping and immunotherapy. The binding specificities, antigen characterization, and isotypes for these MAbs are described.

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## Abstract The distribution of a rat yolkโ€sac antigen (Rat YSAโ€1) as defined by a monoclonal antibody raised against rat yolksac carcinoma cells is described. The antigen is present on rat yolkโ€sac carcinomas, on visceral yolkโ€sac endoderm and on embryonal endoderm of 9โ€dayโ€old embryos. It is not