𝔖 Bobbio Scriptorium
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A rat yolk-sac antigen defined by monoclonal antibodies

✍ Scribed by L. van Hove; H. Sobis; Y. L. Lu; M. Vandeputte

Publisher
John Wiley and Sons
Year
1984
Tongue
French
Weight
935 KB
Volume
33
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

The distribution of a rat yolk‐sac antigen (Rat YSA‐1) as defined by a monoclonal antibody raised against rat yolksac carcinoma cells is described. The antigen is present on rat yolk‐sac carcinomas, on visceral yolk‐sac endoderm and on embryonal endoderm of 9‐day‐old embryos. It is not present on a variety of rat tumors other than yolk‐sac carcinomas and not detectable on pre‐implantation embryos, inner cell mass and fetal endoderm. Rat YSA‐1 differs from alpha‐fetoprotein and Forssman antigen and is species‐specific. In adult rats the only cells displaying this antigen are the spermatozoa and certain cells of the spermatogenic lineage.

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