Cancer treatment according to BRCA1 and BRCA2 mutations
β Scribed by Maxwell, Kara N.; Domchek, Susan M.
- Book ID
- 119960440
- Publisher
- Nature Publishing Group
- Year
- 2012
- Tongue
- English
- Weight
- 160 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1759-4774
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A total of 283 epithelial ovarian cancer families from the United Kingdom (UK) and the United States (US) were screened for coding sequence changes and large genomic alterations (rearrangements and deletions) in the BRCA1 and BRCA2 genes. Deleterious BRCA1 mutations were identified in 104 families (
We have screened index cases from 25 Russian breast/ovarian cancer families for germ-line mutations in all coding exons of the BRCA1 and BRCA2 genes, using multiplex heteroduplex analysis. In addition we tested 22 patients with breast cancer diagnosed before age 40 without family history and 6 patie