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Cancer Risk and GSTM1 and GSTT1 Polymorphisms: Hansteen et al. Respond

✍ Scribed by Inger-Lise Hansteen, Anna Maria Rossi, Roberto Barale, Lisbeth E. Knudsen, Hannu Norppa and Stefano Bonassi

Book ID
124310069
Publisher
Environmental Health Information Service
Year
2009
Tongue
English
Weight
574 KB
Volume
117
Category
Article
ISSN
0091-6765

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## Abstract Isothiocyanates (ITCs) are nonnutrient compounds in cruciferous vegetables with anticarcinogenic properties. ITCs down‐regulate cytochrome P‐450 biotransformation enzyme levels, activate Phase II detoxifying enzymes and induce apoptosis. On the other hand, ITCs also serve as a substrate