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Cancer driver mutations in protein kinase genes

✍ Scribed by Ali Torkamani; Gennady Verkhivker; Nicholas J. Schork


Book ID
116335055
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
219 KB
Volume
281
Category
Article
ISSN
0304-3835

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Oncogenes are altered forms of normal cellular genes known as proto-oncogenes. Several oncogenes encode enzymes that phosphorylate substrate proteins at tyrosine. In most of these cases the oncogene differs from itsproto-oncogene by multiple mutations that alter the structure of the encodedprotein p