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Transforming mutations in protein—tyrosine kinase genes

✍ Scribed by Jonathan A. Cooper

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
924 KB
Volume
4
Category
Article
ISSN
0265-9247

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✦ Synopsis

Oncogenes are altered forms of normal cellular genes known as proto-oncogenes. Several oncogenes encode enzymes that phosphorylate substrate proteins at tyrosine. In most of these cases the oncogene differs from itsproto-oncogene by multiple mutations that alter the structure of the encodedprotein product. Here we discuss how structural changes might effect the regulation and substrate specijicity of the protein kinase product of a protooncogene so that it gains the potential to transform cells.

Rous sarcoma virus Y13 ASV* Gardner-Rasheed FeSV Fujinami ASV, several FeSV Abelson MLV UR2 ASV Avian erythroblastosis virus

McDonough FeSV Rat1 neuroblastoma ? ? ? * Abbreviations: ASV, avian sarcoma virus; FeSV, feline sarcoma virus; MLV, murine leukemia t fps and fes are the avian and feline equivalents of the same proto-oncogene. ** The normal cell genes are named for their protein products. Virus.

P-450 isozyme and future directions that

should lead to a more complete understanding of cytochrome P-450 gene expression in general, particularly as it impacts upon biochemical pharmacology.

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