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Cancer chromosome breakpoints and common fragile sites induced by aphidicolin

โœ Scribed by Frederick Hecht; Thomas W. Glover


Book ID
119102845
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
209 KB
Volume
13
Category
Article
ISSN
0165-4608

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DNA polymerase ฮฑ inhibition by aphidicol
โœ Thomas W. Glover; Carol Berger; Jane Coyle; Barbara Echo ๐Ÿ“‚ Article ๐Ÿ“… 1984 ๐Ÿ› Springer ๐ŸŒ English โš– 987 KB

Aphidicolin, a specific inhibitor of DNA polymerase alpha, is known to induce chromosomal aberrations. At concentrations that did not greatly affect mitotic index, aphidicolin induced a striking number of chromosome gaps and breaks distributed in a highly nonrandom manner in cultured human lymphocyt