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Cancer Chemopreventive Activity of Oleanane-Type Triterpenoids from the Stem Bark of Betula ermanii

✍ Scribed by Chiharu Yamaguchi; Yasuko In; Shun-ichi Wada; Takeshi Yamada; Harukuni Tokuda; Reiko Tanaka

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
247 KB
Volume
6
Category
Article
ISSN
1612-1872

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✦ Synopsis

Abstract

In search for cancer chemopreventive agents from natural sources, three oleanane‐ and four known lupane‐type triterpenoids, and sitosterol from the stem bark of Betula ermanii were tested for their inhibitory effects on Epstein–Barr virus early antigen (EBV‐EA) activation induced by 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA). Among them, 3__β__‐acetoxy‐12__α__‐hydroxyoleanan‐13__β__,28‐olide (1) and 3__β__‐acetoxy‐11__α__,12__α__‐epoxyoleanan‐13__β__,28‐olide (2) were investigated for the inhibitory effect in a two‐stage carcinogenesis test on mouse skin using 7,12‐dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter. 3__β__‐Acetoxy‐11__α__,12__α__‐epoxyoleanan‐13__β__,28‐olide (2) was found to exhibit the potent antitumor promoting activity in the in vivo carcinogenesis test.

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## Abstract In a search for cancer chemopreventive agents from natural sources, four lupane‐type and seven oleanane‐type triterpenoids, and ten synthetic analogs were screened as potential anti‐tumor promoters by using the __in vitro__ short‐term 12‐__O__‐tetradecanoylphorbol‐13‐acetate (TPA)‐induc