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Cancer Chemopreventive Activity of Lupane- and Oleanane-Type Triterpenoids from the Cones of Liquidamber styraciflua

✍ Scribed by Yuko Fukuda; Kuniyoshi Sakai; Shunyo Matsunaga; Harukuni Tokuda; Reiko Tanaka

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
93 KB
Volume
2
Category
Article
ISSN
1612-1872

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✦ Synopsis

Abstract

In a search for cancer chemopreventive agents from natural sources, four lupane‐type and seven oleanane‐type triterpenoids, and ten synthetic analogs were screened as potential anti‐tumor promoters by using the in vitro short‐term 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA)‐induced Epstein–Barr virus early antigen (EBV‐EA) activation assay. Among them, 25‐acetoxy‐3__α__‐hydroxyolean‐12‐en‐28‐oic acid (1) and 3__β__,25‐epoxy‐3__α__‐hydroxylup‐20(29)‐en‐28‐oic acid (2) were examined for anti‐tumor promoting activity in a two‐stage carcinogenesis assay on mouse skin with 7,12‐dimethylbenz[a]anthracene (DMBA) and TPA as promoter. 25‐Acetoxy‐3__α__‐hydroxyolean‐12‐en‐28‐oic acid (1) and 3__β__,25‐epoxy‐3__α__‐hydroxylup‐20(29)‐en‐28‐oic acid (2) showed moderate inhibitory activities.

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Cancer Chemopreventive Activity of Olean
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✍ Chiharu Yamaguchi; Yasuko In; Shun-ichi Wada; Takeshi Yamada; Harukuni Tokuda; R 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 247 KB 👁 1 views

## Abstract In search for cancer chemopreventive agents from natural sources, three oleanane‐ and four known lupane‐type triterpenoids, and sitosterol from the stem bark of __Betula ermanii__ were tested for their inhibitory effects on __Epstein__–__Barr__ virus early antigen (EBV‐EA) activation in