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(+)-Camphor-derived tri- and tetradentate amino alcohols; synthesis and application as ligands in the nickel catalyzed enantioselective conjugate addition of diethylzinc

✍ Scribed by AndréH.M. de Vries; Rosalinde Imbos; Ben L. Feringa

Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 455 KB
Volume: 8
Category: Article
ISSN: 0957-4166
DOI: 10.1016/s0957-4166(97)00145-6

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✦ Synopsis

Several novel tri-and tetradentate amino alcohol ligands, all derived from (+)-camphor, have been synthesized by using specific N-alkylation procedures. The amino alcohols were employed as chiral ligands in the nickel catalyzed conjugate additions of diethylzinc to chalcone and cyclohexenone as model substrates. For the acyclic enone enantioselectivities up to 83% were achieved. (~) 1997 Elsevier Science Ltd

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