Amyloid Ξ² peptide toxicity in differenti
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Tali Vaisid; Nechama S. Kosower; Esther Elkind; Sivia Barnoy
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Article
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2008
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John Wiley and Sons
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English
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## Abstract Amyloid Ξ² peptide (AΞ²) is implicated in the pathogenesis of Alzheimer's disease (AD). The peptide is toxic to neurons, possibly by causing initial synaptic dysfunction and neuronal membrane dystrophy, promoted by increased cellular Ca^2+^. Calpain (Ca^2+^βdependent protease) and caspase