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Calpain and calpain-activated caspase-8 in amyloid-b-peptide toxicity: Attenuation by calpastatin overexpression

✍ Scribed by Kosower, Nechama S.; Vaisid, Tali; Barnoy, Sivia


Book ID
122750296
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
42 KB
Volume
5
Category
Article
ISSN
1552-5260

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Amyloid Ξ² peptide toxicity in differenti
✍ Tali Vaisid; Nechama S. Kosower; Esther Elkind; Sivia Barnoy πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 686 KB

## Abstract Amyloid Ξ² peptide (AΞ²) is implicated in the pathogenesis of Alzheimer's disease (AD). The peptide is toxic to neurons, possibly by causing initial synaptic dysfunction and neuronal membrane dystrophy, promoted by increased cellular Ca^2+^. Calpain (Ca^2+^‐dependent protease) and caspase